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Lung penetration vancomycin doesn't matter!

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Nov 30, - No known active transport mechanisms for vancomycin across membranes and passive transport is responsible for penetration into tissues that are well perfused such as lungs. If only 20% to 30% of vancomycin serum concentration is achieved in lung tissue, higher target concentrations may be required to treat pneumonia.‎Abstract · ‎Vancomycin · ‎Linezolid · ‎Daptomycin.

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SCOPE: A literature review was conducted to investigate the pharmacokinetics and pulmonary and tissue penetration of vancomycin and linezolid.

Vancomycin penetration into lung tissue was evaluated in thirty patients following the administration of 1 g of vancomycin as a 1 h i.v. infusion. A 1 h iv infusion of a 1 g dose of vancomycin does not achieve sustained lung concentrations above the MIC for susceptible staphylococci over a dosing interval of 12 h.

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